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In PRRT2 negative patients, five novel variants in TMEM151A, ATCAY, SCN1A and ANO3 genes was detected through Whole exome sequencing (WES)

OS caused by excessive ROS at physiological levels is likely to affect the functions of hematopoietic stem cells, such as cell growth and self-renewal, which may contribute to defective hematopoiesis

The human 2-Cys peroxiredoxins form widespread, cysteine-dependent- and isoform-specific proteinprotein interactions

The dsDNA hairpin was obtained by PCR amplification with Phusion High-Fidelity DNA Polymerase (Thermo Scientific) using Lambda DNA (New England Biolabs) as template and oligonucleotides that include different BsaI restriction sites in each side of the PCR fragment (see Supplementary Tables 3 and 4 for oligonucleotides) followed by purification (QIAGEN) as described previously 47