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On one side, sulfasalazine inhibits cystine uptake and decreases GSH and GPX4 levels by inhibiting the system Xc

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[DOI] [PubMed] [Google Scholar] 28.Ito Y, Miyauchi A, Oda H, Masuoka H, Higashiyama T, et al

It is crucial to identify the core targets that lead to pathological changes from quantitative to qualitative changes during this process, and the above preventive interventions, sleep improvement, physical exercise, dietary regulation, and social intervention, may prolong or reverse the subclinical pathological stage (Fig