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Because effect sizes vary by indication, dosing, individual factors, and adherence, a thoughtful provider frames frequency as something to reassess rather than fix permanently

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2 The intestinal barrier 2.1 Structure of intestinal barrier The intestinal barrier is a highly specialized and dynamic structure that regulates the selective absorption of essential nutrients, electrolytes, and water, while simultaneously protecting the host from luminal pathogens, toxins, and antigens (Zhang et al., 2023)