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Indeed, genetic deletion of GSDMD, CASP8, or NLRP12 reduced RGC death after the transient IOP elevation model, where IOP was elevated to 110 mmHg for 90 min ( Given that oxidative phosphorylation in the mitochondria is dependent on oxygen and is the main source of cellular ATP in addition to glycolysis, hypoxia and glucose deprivation decrease ATP, facilitate K + efflux, and induce IL-1 release