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These include mitogen-activated protein kinase and nuclear factor-B (NF-B), which lead to the expression of inflammatory cytokines, chemokines, and adhesion molecules

In plants exposed to temperature extremes, heavy metal-contaminated soils, drought, or air pollutants, the generation of reactive oxygen species and alterations in the intracellular redox environment perturb cellular physiology (Ogawa, 2005)

Globular proteins are more soluble in aqueous solutions, and are generally more sensitive to temperature and pH change than are their fibrous counterparts