foxo4-dri senolytic peptide mechanism Class II senolytics inhibit survival pathways elicited by senescent Development of a novel senolytic

Development of a novel senolytic by precise disruption of FOXO4 p53 complex eBioMedicine The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. Peptide Inhibitors Targeting FOXO4 p53 Interactions and Inducing Senescent Cancer Cell specific Apoptosis Journal of Medicinal Chemistry Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway

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