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Leptin stimulates migration and invasion and maintains cancer stemlike properties in gastric cancer cells

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Epub 2019 Mar 27

Based on these studies, we propose a conceptual framework of "Reciprocal Tumor-Lung Metastatic Symbiosis" (RTLMS) that is analogous to the concept of ecology, namely tumor cells achieve "parasitic adaptation" by remodeling the LPMN, while lung-derived chemokines (e.g., CXCL12) actively recruit CTCs to form a mutually beneficial pathological synergy