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Introduction Cisplatin is an alkylating agent used to treat several types of cancers that works by causing DNA lesions via the formation of intrastrand and interstrand crosslinks, resulting in the activation of various signal-transduction pathways that block cellular processes, such as replication and transcription

Int J BiolMacromol 81:427434 Jayne D, Blockmans D, Luqmani R, Moiseev S, Ji B, Green Y, Hall L, Roth D, Henderson RB, Merkel PA, BREVAS Study Collaborators (2019) Efficacy and safety of belimumab and azathioprine for maintenance of remission in antineutrophil cytoplasmic antibodyassociated vasculitis: a randomized controlled study

This process is driven by ATP6V0D2, a vesicular H + pump, which plays a role in other important pathways in the macrophage (43) and is inhibited by pantoprazole in other cell types (4446)

Yin H, Hu M, Liang X, et al