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The MSH-dependent alcohol dehydrogenase MscR (MSNO reductase/formaldehyde dehydrogenase) catalyzes the detoxification of formaldehyde and S -nitrosyl-mycothiol (MSNO) (Newton et al., 2008)

6 cells/ml (OD 600 0.37)

Inhibition of DRP1 expressions or activity has been shown to significantly suppress tumor cell proliferation, invasion, and migration, while enhancing apoptosis and increasing synergistic responses to chemotherapy and radiotherapy [47, 48]

If conjugation of HMCDs with anti-neoplastic agents increases the intracellular drug concentration, it is likely the conjugate will bind to different, or additional drug targets, increasing the potency relative to the unconjugated drug