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Histone methylation has complex biological roles, as it varies in its precise localization on the histone sequences and its co-existence with other PTMs (Sidoli and Garcia, 2017)

Front Immunol (2018) 9:850

In other tissues, BPA is reported to increase expression of the estrogen-responsive genes cyp19a1b ( Aromatase B , neural aromatase), esr1 ( ER ), and esr2 ( ER ) and decrease expression of thyroid receptors TRa ( thraa, thrab ) and TRb ( thrb )