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The key metabolites produced during this process maintain the Warburg effect [40, 41], and at the same time act as substrates, cofactors, or allosteric regulators for epigenetic enzymes (such as DNA methyltransferases (DNMTs) and ten-eleven translocases (TETs), thereby directly regulating their activity [8]

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Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community