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Zero adverse events across all groups No adverse events were reported in any of the three groups over the full 6-month treatment period

Second, NNMT depletes that universal methyl donor, SAM, which is essential for DNA methylation, neurotransmitter production, and other indispensable biological processes

It can be used alongside caloric restriction without exacerbating hunger, combined with exercise programs without compromising fueling needs, or integrated with behavioral nutrition approaches that rely on intact hunger and satiety signaling for long-term habit formation

These combinations should generally be avoided or approached with caution, as sermorelin may be ineffective if somatostatin analogs are on board