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Science 257: 14961502 JessopCE,BulleidNJ (2004) Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells

Nature 428:950-955, 2004

Brepocitinib, a JAK1 and TYK2 inhibitor, demonstrated clinically meaningful hair regrowth in patients with cicatricial alopecia, while ritlecitinib, a JAK3 and TEC kinase inhibitor, showed significant hair regrowth in patients with alopecia totalis or universalis

244 Upon pressure overload, lysosomal deoxyribonuclease (DNase) II deficiency in cardiomyocytes leads to mtDNA accumulation in autolysosomes, which subsequently activates TLR9 signaling-mediated inflammatory responses, contributing to heart failure