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Our study establishes that dietary-derived PUFAs trigger neutrophilic inflammation in the small intestine resembling some aspects of human CD

Matsufuji S, Kitajima Y, Higure K, et al

CD36 binding activates PI-3K/AKT1 prosurvival pathways and reduces oxidative stress in cardiomyocytes, with evidence from ischaemia/reperfusion models confirming that GHRP-2 attenuates cardiomyocyte death and preserves left ventricular function

Thus, clinically apparent liver injury attributable to ashwagandha occurs although rarely, and its use should be avoided in patients with cirrhosis or advanced chronic liver disease