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Immunophenotyping assays have demonstrated expression of TRPM3 ion channels to be significantly reduced and significantly increased in different NK cells and CD19 + B-cells subsets, respectively, in ME/CFS donors compared with healthy controls [86, 87]

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The current classification includes 13 types of Ehlers-Danlos syndrome: Arthrochalasia EDS Brittle Cornea Syndrome Cardiac-valvular EDS Classical EDS Classical-like EDS Dermatosparaxis EDS Hypermobile EDS Kyphoscoliotic EDS Musculocontractural EDS Myopathic EDS Periodontal EDS Spondylodysplastic EDS Vascular Ehlers-Danlos Syndrome EDS is often misunderstood