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Clinical studies have carefully documented this effect, often using Visual Analogue Scales (VAS) for subjective hunger ratings and carefully measured food consumption data to quantify caloric intake increases

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These observations, together with the fact that spine head size and geometry are associated with AMPA receptor content and maturation status (Matsuzaki et al., 2001), suggest that MET signaling may control many aspects of glutamatergic synapse development, including the timing of excitatory synapse maturation (Qiu et al., 2014)

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