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It could inhibit ferroptosis by activating the Nrf-2/HO-1 pathway in db/db mice and HK-2 cells induced by high glucose, thereby retarding the progression of DKD[166]

Iron plays a direct role in oxygen transport, and deficiency quickly shows in weak movement, pale mucous membranes, and poor weight gain

Table 3: Clinical Trials and Meta-Analyses of Antioxidants and Chemotherapy Antioxidant Drugs Used With Chemotherapy Aside from the controversy surrounding antioxidant supplements in chemotherapy, readers may be unaware that several FDA-approved antioxidant drugs are regularly used to reduce chemotherapy-associated side effects (Moss 2006)