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NAD+ is the oxidized form that triggers repair and longevity genes, while NADH is the reduced form that carries electrons to produce energy

The activated beta-3 receptor couples to stimulatory G-proteins (Gs), which activate the enzyme adenylyl cyclase

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Sema4D/3C -induced translocation of GR to the nucleus is dependent on an intact NLS [34], pointing to the involvement of Ran and importins in this process