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The GHRP-2 test shows comparable sensitivity and specificity to insulin tolerance testing with a superior safety profile Body composition : Phase 2 studies examining effects on body composition, showing trends toward increased lean mass and decreased fat mass with repeated dosing Synergy with GHRH : Key studies demonstrating that combined GHRP-2 + GHRH administration produces GH release 2-3 times greater than either agent alone, establishing the mechanistic basis for combination protocols Aging studies : Research showing that GH responses to GHRP-2 are preserved in elderly subjects to a greater degree than responses to GHRH alone, suggesting maintained GHS-R1a sensitivity with aging Cardiac effects : Preclinical evidence of cardioprotective properties through GHS-R1a activation, independent of GH release The primary limitation is that GHRP-2 has not progressed beyond Phase 2 development for any therapeutic indication

Total and vertebral BMD unchanged

Whether senescent cells also activate mechanisms protecting against other types of cell death is unclear

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