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Additionally, no decrease in disc height and no change in Pfirrmann score were reported, with 3 patients showing signs of increased NP hydration at the final follow-up

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discovered that the accumulation of unfolded proteins in the mitochondrial matrix resulted in transcriptional upregulation of nuclear-encoded mitochondrial stress genes, including hsp60, hsp10, mtDnaJ, and ClpP, without interfering gene expression that was related to endoplasmic reticulum (ER) stress