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Curcumin moderates inflammatory response by suppressing the activity of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and lipoxygenase enzymes as well as inhibiting the production of interleukin 1,2,6,8 and 12, inflammatory cytokines tumor necrosis factor-alpha (TNF-), monocytes chemoattractant protein (MCP) and the down regulation of Janus and mitogen-activated kinase 3,69,70