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The resulting ROS can impair DNA, increase lipid peroxidation, lead to arteriosclerosis, destroy the extracellular matrix, stimulate bone erosion, activate osteoclasts, increase inflammation, and finally destroy joints [39]

Hydrogen peroxide is then degraded by GPx-1 into water

ema.europa.eu/en/ich-q2r2-validation-analytical-procedures-scientific-guideline European Medicines Agency

Pizzorno (2014): Reviewed glutathione as the most important antioxidant in human physiologycritical for detoxification, mitochondrial health, and immune resilience