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Thus, bioactive compounds become more important not only as therapeutic agents to treat diseases and disorders but also as useful chemical tools to examine their complex biological processes in vitro and in vivo [30]

The upregulation of key glycolytic enzymes, such as hexokinase 2 (HK2), pyruvate kinase M2 (PKM2), and lactate dehydrogenase A (LDHA), remains a hallmark of many NSCLC tumors [12, 13]

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While composite resin fillings are tooth-colored, more aesthetic, and free from mercury, they tend to wear down more quickly and may not last as long in high-pressure areas