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Conversely, some studies have found no relationship between B12 deficiency and sensorimotor symptoms, indicating that neurological findings are not always similar across studies

Current therapeutic strategies for OA-BMLs include non-weight-bearing protocols, pharmacological interventions such as diphosphonates (bone resorption inhibitors), prostaglandin I (PGI), and strontium ranelate (SrRan, a bone turnover inhibitor), as well as surgical approaches like bracing, subchondroplasty (bone substitute injection), high tibial osteotomy (HTO), unicompartmental knee arthroplasty (UKA), and total knee arthroplasty (TKA) [23]

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IGF-I and IGFBP-3 levels increase slowly from birth until a more rapid increase and peak during puberty, which is followed by a decline toward low levels in senescence (50, 51) (Figure 2)