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Freezing reconstituted peptides causes ice crystal formation, which physically disrupts the molecular structure and promotes aggregation

The transducers interact with the intracellular multisubstrate docking site of MET either directly, such as GRB2, SHC, [16] SRC, and the p85 regulatory subunit of phosphatidylinositol-3 kinase (PI3K), [16] or indirectly through the scaffolding protein Gab1 [17] Tyr 1349 and Tyr 1356 of the multisubstrate docking site are both involved in the interaction with GAB1, SRC, and SHC, while only Tyr 1356 is involved in the recruitment of GRB2, phospholipase C (PLC-), p85, and SHP2

Patients who had significant swelling often report visible reduction