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During an infectious condition, however, an increase in DIO2 activity leads to higher levels of hypothalamic T3, which might be the molecular mechanism associated to the central hypothyroidism observed in the nonthyroidal illness syndrome (37)

Nature 537: 347355 Bache N, Geyer PE, BekkerJensen DB, Hoerning O, Falkenby L, Treit PV, Doll S, Paron I, Muller JB, Meier F et al (2018) A novel LC system embeds analytes in preformed gradients for rapid, ultrarobust proteomics

Similarly, they must be aware of the transient nature of the therapeutic benefits and that there may need repeated injections

Diabetologia (2010) 53(6):101932