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The nanoparticles effectively reduced infarct volume, neurological dysfunction, neutrophil infiltration and neuronal apoptosis, while suppressing pro-inflammatory cytokines (TNF- and IL-8) and upregulating anti-inflammatory cytokines (IL-10 and TGF-1) (211)

doi: 10.4103/0975-1483.100022

[DOI] [PubMed] [Google Scholar] Hassanein EHM, Ibrahim IM, Abd-Alhameed EK, Sharawi ZW, Jaber FA, Althagafy HS

46 recommended that naloxone could be used as an antidote for kratom toxicity, and for sympathetic symptoms such as hypertension, mydriasis and tachycardia, labetalol could be used