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and one or more soaps, which themselves may be characterized as sur R 1 and R 2 may be the same or different, and comprise at least one group selected from the group consisting of C 1 -C 6 alkyl, optionally the C 1 -C 6 alkyl may include one or more of oxygen, nitrogen, or sulfur atoms or groups that include at least one of these atoms, and the alkyl chain may be optionally substituted with one or more substituents selected from the group consisting of hydroxyl, amino, amido, sulfonyl, sulfonate, carbonyl, carboxyl, and carboxylate

In a phase 3 trial involving adults with overweight or obesity (BMI 28 kg/m, or 24 kg/m with at least one weight-related comorbidity) without diabetes, treatment with 2.4 mg ecnoglutide produced a mean body weight reduction of 13.2% at 40 weeks

10.1016/S0896-6273(01)00264-1 Neuron 148 PratM.CrepaldiT.PennacchiettiS.BussolinoF.ComoglioP

As a result, the distribution of occludin within the intercellular junction complex decreases, the interstitial space expands, and endotoxins, including bacterial LPS, can enter the portal circulation (Li et al., 2013)