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While the peptides activation of ENC-alpha in the lungs is a good thing in pneumonia where fluid literally interferes with breathing, the investigators were concerned that activating ENaC-alpha in the kidneys might disturb normal sodium retention, which is important to the kidneys role in blood pressure regulation

However, some experts have established a link between obesity and chronic systemic inflammation, which can lead to the development of medical conditions that can cause fluid buildup in the tissues surrounding the carpal tunnel

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[26] During a six-month clinical trial, participants lost on average 25 lbs each