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Risk and Handling Precautions Risk Tier: MODERATE This rating reflects both peptides' bioactive activity at angiogenic and cytoskeletal signaling pathways in preclinical models, the absence of established human safety profiles for either compound, and the additional handling considerations specific to intranasal formulations

Microbiome 5 (1), 105

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Neither peptide has an established human safety profile for neurological use, and the safety data that do exist are narrow, short-term, and drawn from other tissues