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In addition to the endogenous cellular pathways, recent studies have also investigated the role of the gut microbiome in affecting NAD + levels

ACS Infect Dis 6:29502958 Van de Ven H, Vermeersch M, Matheeussen A, Vandervoort J, Weyenberg W, Apers S, Cos P, Maes L, Ludwig A (2011) PLGA nanoparticles loaded with the antileishmanial saponin -aescin: Factor influence study and in vitro efficacy evaluation

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Despite progress in cancer treatment and the introduction of new drugs and small molecules (anti-cancer agents and chemotherapeutics), it is essential to concentrate more on the key mechanisms involved in tumorigenesis, as cancer cells can become resistant to treatments