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Subcutaneous dosing of female rats from before mating through gestation and lactation and allowed to deliver caused maternal dystocia and periparturient mortality, increases in stillbirths and neonatal deaths, and reduced pup body weight starting at doses equivalent to 0.1 times the human 5 mg intravenous dose (based on AUC) (see Data)

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Preparations containing preservatives should not be introduced into the cerebrospinal fluid due to the risk of neurotoxic effects on neural tissue

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