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As an evolutionary strategy to counteract truncation-induced toxicity resulting from impaired proteostasis, the cellular system employs compensatory responses such as phosphorylation near truncation sites

It is one of the most common forms of cancer in women but can also be found in men, albeit less frequently ( Figure 1 )

165 A meta-analysis of 13 randomized controlled trials with a total of 1,345 participants found standard medical treatment plus tinnitus retraining therapy led to higher response rates after one, three, and six months, and reduced tinnitus-related disability more than medical treatment alone

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