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This paper aims to explore the main bioactive metabolites of PPE and its applications in biomedicine (Figure 1), while providing an in-depth analysis of its limitations in practical applications and its development potential

Estrogen-responsive element (ERE) in the Nrf2 promoter region can also be directly activated by ER to promote Nrf2 transcription [190]

Conversely, leptin receptor deficient db/db mouse model of type 2 diabetes demonstrated increased BBB permeability, as compared to db/+ control mice (Yu et al., 2019)