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[36] Diagnosis [edit] The diagnosis of dermatomyositis is based on five criteria, which are also used to differentially diagnose with respect to polymyositis: [33] Muscle weakness in both thighs or both upper arms Using a blood test, finding higher levels of enzymes found in skeletal muscle, including creatine kinase, aldolase, and glutamate oxaloacetate, pyruvate transaminases and lactate dehydrogenase Using electromyography (testing of electric signalling in muscles), finding all three of: erratic, repetitive, high-frequency signals

As the rate-limiting enzyme in the oxidation of LCFAs, CPT1 has three isoenzymes, CPT1A, CPT1B and CPT1C, which exhibit significantly different kinetic and regulatory properties

1997;273(5 Pt 2):R1764-1770