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In the case of BBB dysfunction, vitamin E has been shown to reduce oxidative stress, preserve endothelial cell integrity, and enhance the expression of tight junction proteins

When it was found that foods containing NAD+ precursors, particularly vitamin B3, may treat the fatal illness pellagra, which is characterized by diarrhea, dermatitis, dementia, and death, the clinical significance of maintaining NAD+ levels was established in the early 1900s