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In addition, we show that inhibition of ferroptosis can result in attenuation of A-related lipid peroxidation and an increase in the expression of iron storage proteins in brain cortical organoids differentiated from iPSCs of AD patients compared to their isogenic controls

In research models, this makes it useful for examining how reduced NNMT activity changes intracellular nicotinamide handling, methyl donor utilization, and downstream metabolic signaling