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One of the key mechanisms through which nicotinamide may exert these protective effects is by restoring the levels of nicotinamide adenine dinucleotide (NAD+), which is critical for mitochondrial metabolism and energy production

doi: 10.1136/bjo.86.12.1369

Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG (1996) Proteinprotein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase

37 reported decreased k cat app and increased K m app (GSSCys) values upon replacement of Lys19 in a single cysteine mutant of human Grx1