10.1016/j.metabol.2021.154708 Metabolism 148 LuY.LiZ.ZhangS.ZhangT.LiuY.ZhangL
Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation
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Luuk Hoegen Dijkhof, Anna Drzazga, Pierre Sabatier, Tomasz Stepniewski, Louise Granlund, Maico Lechner, Yi Zhong, Lrke Smidt Gasbjerg, Bolette Hartmann, Volker Lauschke, Jens Juul Holst, Jesper Velgaard Olsen, Olle Korsgren, Jana Selent, Read the full open-access article here: Cell Press Congratulations on this outstanding work