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Within nonalcoholic steatohepatitis (NASH)-related HCC, the presence of cirrhosis significantly alters primary conjugated BA levels and correlates with specific microbial shifts, such as Lactobacillus enrichment, which is linked to disease progression ( This variability extends to extra-intestinal sites like breast cancer, where intratumoral BA metabolism scores and microbial compositions are associated with proliferation and survival (170)

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