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In some embodiments, one or more of the compounds 101-105 have a synergistic effect with one or more of the above umami flavor compounds or combinations of umami flavor enhancing compounds

25 More recent studies have also linked vitamin D deficiency to sickle cell disease, aromatase inhibitorinduced arthralgia, headache, PHN, pain in patients taking high doses of opioids, and various types of musculoskeletal and orthopedic pain