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The following should be undertaken: (a) Trained personnel (wearing appropriate protective clothing and breathing apparatus if hydrogen cyanide or liquid cyanide preparations are involved) should * terminate further exposure * commence artificial ventilation with 100% oxygen a * administer 0.2-0.4 ml amyl nitrite via Ambu bag (b) A physician (if immediately present on the scene) should * terminate further exposure * artificial ventilation with 100% oxygen a * administer 0.2-0.4 ml amyl nitrite via Ambu bag In cases of unequivocal moderate to severe poisoning, the above procedure should be followed by 50 ml of 25% sodium thiosulfate solution (12.5 g) i.v

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Moreover, in an in vitro model of blast-induced auditory hair cell damage, 3-AB inhibition of PARP1 reduced oxidative stress markers, upregulated antioxidant defenses, and helped maintain cell viability by preserving ATP pools 175

doi: 10.1038/414813a