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Karey KP and Sirbasku DA

The link between the shortened G0G1 phase and the activation of these proteins suggests that the combination treatment enhances the regulatory control exerted by p21 and p27, facilitating a quicker transition through the G1 phase

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This design was based on practical constraints common in large animal trials (such as rearing costs and infrastructure) and aimed to capture large-effect changes in key indicators (e.g., ADG)