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Safety and tolerability of the 1-day regimen were consistent with the known profile of aripiprazole

The precise regulation of ALS pathogenetic mechanisms is still elusive, despite the abundance of identified mechanisms mediating MN degeneration and death, including neuroinflammation, glutamate excitotoxicity, altered RNA metabolism, mitochondrial dysfunction, impaired cytoskeletal integrity, altered axonal transport dynamics, OS [71, 84, 85]

Francoleon, N

This would suggest the role of -arrestin2 in the stabilization of dopamine receptor signaling and overcoming the plasticity induced by chronic levodopa treatment