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Sarhan, 2018)

Through weakening innate and adaptive immune responses, zinc deficiency diminishes the capacity of the body to combat pathogens (63, 64)

Growing evidence indicated that microbiota dysbiosis, occurring when the diversity, composition, and/or functions of the intestinal microbiome are disrupted, could contribute to the alteration of the IEB with implications in the development, progression, and symptom flare-up of several diseases

Additionally, therapeutic interventions that target MAPK signaling, such as the use of sakuranetin, have demonstrated efficacy in reducing eosinophilic lung inflammation and Th2/Th17 cytokine production by inhibiting the activation of ERK1/2, JNK, and p38 MAPKs [165]