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however, the nigral striatal pathway may be impaired, and nigral cell loss or loss of striatal cellular elements may occur

In mice, it has been found that DIM also attenuates colonic inflammation and tumorigenicity in a mouse colitis model and an azoxymethane (AOM)/DSS induced colon cancer model (148)

In current clinical trials, patients are recommended to use HCQ at a dosage of 5 mg/kg body weight or less in order to minimize the risk of retinal complications, even during pregnancy and breastfeeding (99)

While not primarily a fat loss compound, these effects support body recomposition when combined with appropriate training and nutrition