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BioMed Pharmacother (2022) 151:113092

Many patients add the HIFU Treatment in the weeks following a successful cycle to address skin tone and firmness as fat reduces

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As one of the main active components of PM, rhein could up-regulate the mRNA and protein levels of Nrf2, HO-1, and glutamate-cysteine ligase catalytic subunit (GCLC), down-regulate the protein expression of NF-B, TNF- and caspase-3, increase the survival rate of LO2 cells, decreasing the apoptosis rate and acting as a hepatoprotective drug (Li et al., 2021b)