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Recently, Xu Guowang, a researcher of the Biomolecular High-resolution Separation Analysis and Metabolomics Research Group of the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, and the National Cancer Institute (NCI) researcher Yang Chunzhang, have made new progress in the treatment of isocitrate dehydrogenase 1 (IDH1) mutant glioma, revealing the importance of the glutathione (GSH) metabolic pathway regulated by Nrf2, and a new strategy for the intervention of glutathione metabolism in the treatment of gliomas is proposed

Dubbed Truqap, the new treatment is approved in combination with Astras Faslodex

The majority of folate entering tissue cells is in the form of 5-methyl-THF monoglutamate or is quickly metabolized to this form, which has a low affinity for folylpolyglutamate synthetase 894

Tumor Biol 2013;34(3):1855-1863