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667 Notably, as zinc is essential for heme synthesis, which is recognized as increased in the brain of AD sufferers leading to oxidative stress, clioquinols binding to zinc reduces heme synthesis and oxidative stress

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Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia Email: [email protected] ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 2 American MD Program, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Affiliation: 1 Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia ORCID: Explor Cardiol

Conversely, under specific conditions, glutaredoxins which depend on glutathione for their activity can also reduce oxidized thioredoxins