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Side Effects: Side effects that are most common include gastrointestinal upset such as anorexia, decreased appetite, vomiting, and/or diarrhea as well as less commonly possible lethargy, tremors, neurologic signs, and worsening arrhythmias

PI3K converts PIP2 to PIP3 at the inner leaflet of the plasma membrane, which recruits Akt and PDK1

The binding patterns we observe between different di-nucleosome baits are complex and highlight an important point and a unique benefit of measuring apparent affinities from complex lysates: we measure the average binding profile over what is likely a pool of heterogeneous multimeric protein complexes

Cyp7a1 in the CV area serves as a pivotal enzyme in cholesterol metabolism, leading to the predominant synthesis of bile acids in CV area hepatocytes